Diabetes · 2026
Longitudinal Repeated Protein Measurements in a Multiethnic Cohort Identify Novel Diabetes Biomarkers That Reveal Unique Disease Pathways.
СтатьяНазвание и аннотация: Перевод в очереди
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Chen Zsu-Zsu, Mi Michael Y, Barber Jacob, Tiwari Gaurav, Adams Charleen D, Deng Shuliang, Shin Christopher Y, Farrell Laurie, Rao Prashant, Cruz Daniel E, Wilson James G, Sevilla-Gonzalez Magdalena, Chen Yii-Der Ida, Guo Xiuqing, Goodarzi Mark O, Taylor Kent D, Tahir Usman A, Rich Stephen S, Wood Alexis C, Gerszten Robert E, Rotter Jerome I
Аннотация
There is up to a fourfold increase in diabetes biomarkers identified with longitudinal repeated versus single time point proteomic measurements. The increase in biomarkers identified with longitudinal repeated measurements is supported by a similar proportion being nominated as causal for type 2 diabetes with Mendelian randomization. Proteins unique to the longitudinal repeated analyses highlighted biological pathways (e.g., posttranslational protein modification and cellular structure and cycle regulation) that were distinct from pathways enriched among the shared proteins (e.g., small-molecule metabolic and catabolic processes). Longitudinal protein measurements identify additional novel disease biomarkers and disparate biological pathways compared with single measurement analyses.