Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego · 2009
[The effect of sulpiride on intensity of gastroesophageal reflux].
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Mokwińska Marzena, Chojnacki Cezary
Аннотация
UNLABELLED: Drugs inhibiting gastric acid secretion are most commonly used in a long-term treatment of GERD. In a number of patients their therapeutic effects are not satisfactory enough. For that reason other medicines are added as a concomitant therapy, e.g., prokinetics. Adverse drug reactions of widely available prokinetics limit their application and inspire us to search for different pharmacological compounds
THE AIM OF THE STUDY: To evaluate if sulpiride can prevent episodes of gastroesophageal refluxes.
MATERIALS AND METHODS: The study comprised 25 men, aged 26-58 years, suffering from GERD, with erosive oesophagitis of A and B grades according to Los Angeles classification. In each subject 24-hour oesophageal pH-metry (Digitrapper Marc III, Synectics) was performed three times: prior to sulpiride administration, after the first two doses of 50 mg and after 6 weeks of treatment in the daily dose of 2 x 50 mg. On the day of the measurements patients remained on a standard liquid diet (Nutridrink 3 x 400 ml).
RESULTS: The initial reflux index prior to the drug administration was 18.8 +/- 10.7; after the first two doses it was 13.6 +/- 9.9 (p = 0.020), whereas after 6 weeks of therapy it was 16.3 +/- 10.1 (p = 0.034). The De Meester scores were: 74.0 +/- 52.3; 53, 4 +/- 41.9 (p = 0.002) and 56, 6 +/- 38.7 (p = 0.014) respectively.
CONCLUSIONS: Sulpiride reduces intensity of gastroesophageal refux. Sulpiride can be considered in the combined treatment of GERD.
THE AIM OF THE STUDY: To evaluate if sulpiride can prevent episodes of gastroesophageal refluxes.
MATERIALS AND METHODS: The study comprised 25 men, aged 26-58 years, suffering from GERD, with erosive oesophagitis of A and B grades according to Los Angeles classification. In each subject 24-hour oesophageal pH-metry (Digitrapper Marc III, Synectics) was performed three times: prior to sulpiride administration, after the first two doses of 50 mg and after 6 weeks of treatment in the daily dose of 2 x 50 mg. On the day of the measurements patients remained on a standard liquid diet (Nutridrink 3 x 400 ml).
RESULTS: The initial reflux index prior to the drug administration was 18.8 +/- 10.7; after the first two doses it was 13.6 +/- 9.9 (p = 0.020), whereas after 6 weeks of therapy it was 16.3 +/- 10.1 (p = 0.034). The De Meester scores were: 74.0 +/- 52.3; 53, 4 +/- 41.9 (p = 0.002) and 56, 6 +/- 38.7 (p = 0.014) respectively.
CONCLUSIONS: Sulpiride reduces intensity of gastroesophageal refux. Sulpiride can be considered in the combined treatment of GERD.