Annals of medicine and surgery (2012) · 2026
Transient paresthesia following polymyxin B loading dose in a critically ill patient: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Joshi Albin, Bogati Safal, Khakurel Sharad, Acharya Santosh, Kunwor Puskar
Аннотация
BACKGROUND: Polymyxins, including colistin and polymyxin B, are considered salvage therapy to treat infections caused by multidrug-resistant gram-negative bacteria. Despite their importance, the clinical use of polymyxins is often constrained by their narrow therapeutic index, especially due to nephrotoxicity and neurotoxicity. Paresthesia associated with polymyxin B is often underreported, not fully understood, and only a few cases highlight this.
CASE PRESENTATION: We present a case of transient paresthesia occurring shortly after the administration of a loading dose of polymyxin B in a critically ill 33-year-old South Asian woman with intra-abdominal sepsis. Interestingly, the symptoms resolved spontaneously despite the continuation of the maintenance regimen.
CONCLUSION: This case highlights the under-recognized neurotoxic potential of polymyxin B, particularly during loading doses, and underscores the importance of vigilance and individualized clinical judgment when balancing antimicrobial efficacy with tolerability.
CASE PRESENTATION: We present a case of transient paresthesia occurring shortly after the administration of a loading dose of polymyxin B in a critically ill 33-year-old South Asian woman with intra-abdominal sepsis. Interestingly, the symptoms resolved spontaneously despite the continuation of the maintenance regimen.
CONCLUSION: This case highlights the under-recognized neurotoxic potential of polymyxin B, particularly during loading doses, and underscores the importance of vigilance and individualized clinical judgment when balancing antimicrobial efficacy with tolerability.