JCO precision oncology · 2026
Diffuse Pleural Mesothelioma in Young (Age ≤50 Years) and Very Young (Age ≤35 Years) Patients: Clinical Characteristics, Genomics, and Survival.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ollila Hely, Tidjani Amina, Sauter Jennifer L, Yang Soo-Ryum, Simone Charles B, Offin Michael, Adusumilli Prasad S
Аннотация
PURPOSE: Although we typically consider diffuse pleural mesothelioma (DPM) as a disease of elderly males with a history of asbestos exposure, young individuals are also affected. Given the increasing incidence of cancer in young individuals, we investigated the characteristics and underlying biology of young patients with DPM.
METHODS: We identified patients with DPM age ≤50 years from Memorial Sloan Kettering Cancer Center (1990-2023). Clinicopathologic and genetic characteristics were compared between very young (≤35 years) and young (36-50 years) patients.
RESULTS: We identified 273 patients with DPM age ≤50 years; 39% were female, 40% had a history of self-reported occupational asbestos exposure (very young, 16% v young, 45%; P < .01), 16% had a personal history of cancer (very young, 7% v young, 18%; P = .07), and 70% had a family history of cancer (most commonly breast, lung, and colon). Most frequently altered somatic genes (51/273 tested; 46/51 positive) included BAP1 (22/47, 47%), NF2(18/47, 38%), CDKN2A/B (12/48, 25%), and TP53 (10/48, 21%). Very young patients had less somatic alterations in BAP1 (13% v 63%, P < .01) and a lower tumor mutational burden (0.9 v 1.8 mut/mB, P < .01); they were less frequently carriers of germline alterations (0% [0/8] v 43% [6/14], P = .05). Somatic alterations in CDKN2B were more frequent among females (females 42% v males 12%, P = .03).
CONCLUSION: Young patients with DPM have strong personal and family histories of cancer, and heterogeneous somatic and germline alterations, indicating divergent underlying biology. With the increasing prevalence of young adults with cancers, mesotheliomas, although uncommon, should be on the differential for patients even without asbestos exposure history in this age group.
METHODS: We identified patients with DPM age ≤50 years from Memorial Sloan Kettering Cancer Center (1990-2023). Clinicopathologic and genetic characteristics were compared between very young (≤35 years) and young (36-50 years) patients.
RESULTS: We identified 273 patients with DPM age ≤50 years; 39% were female, 40% had a history of self-reported occupational asbestos exposure (very young, 16% v young, 45%; P < .01), 16% had a personal history of cancer (very young, 7% v young, 18%; P = .07), and 70% had a family history of cancer (most commonly breast, lung, and colon). Most frequently altered somatic genes (51/273 tested; 46/51 positive) included BAP1 (22/47, 47%), NF2(18/47, 38%), CDKN2A/B (12/48, 25%), and TP53 (10/48, 21%). Very young patients had less somatic alterations in BAP1 (13% v 63%, P < .01) and a lower tumor mutational burden (0.9 v 1.8 mut/mB, P < .01); they were less frequently carriers of germline alterations (0% [0/8] v 43% [6/14], P = .05). Somatic alterations in CDKN2B were more frequent among females (females 42% v males 12%, P = .03).
CONCLUSION: Young patients with DPM have strong personal and family histories of cancer, and heterogeneous somatic and germline alterations, indicating divergent underlying biology. With the increasing prevalence of young adults with cancers, mesotheliomas, although uncommon, should be on the differential for patients even without asbestos exposure history in this age group.