A history of breast cancer and older age allow risk stratification of mammographic BI-RADS 3 ratings in the diagnostic setting.

OBJECTIVE

The objective was to investigate whether risk stratification of mammographic Breast Imaging: Reporting and Data System (BI-RADS) 3 can be accomplished in the diagnostic setting.

METHODS

We analyzed 4941 BI-RADS-3-rated patients (23 malignant outcomes) and built logistic-regression models with age, personal and family history of breast cancer, fibroglandular density, and additional mammographic findings as predictive variables.

RESULTS

A personal history of breast cancer (odds ratio: 5.53) and older age (odds ratio: 12.44/10.93 for age 50-64/>64) are independent risk factors. Patients with both risk factors have a risk >2%.

CONCLUSION

Biopsy may be warranted in older patients with a history of breast cancer who would be otherwise assigned BI-RADS 3.