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DOI 10.1016/j.breast.2010.10.004

Медицинская библиотека · Breast (Edinburgh, Scotland) · 2010

Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort.

Beckmann K R, Buckingham J, Craft P, Dahlstrom J E, Zhang Y, Roder D, Stuart-Harris R

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

PURPOSE: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort.

METHODS

Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors.

RESULTS

Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21].

CONCLUSION

Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

Для цитирования: Beckmann K R, Buckingham J, Craft P, Dahlstrom J E, Zhang Y, Roder D, Stuart-Harris R. Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort.. Breast (Edinburgh, Scotland). 2010. DOI: 10.1016/j.breast.2010.10.004.

Предметные рубрики MeSH

AustraliaBreast NeoplasmsCohort StudiesFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasms, Multiple PrimaryNeoplasms, Second PrimaryProportional Hazards ModelsProspective StudiesRisk Factors
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