Nature genetics · 2010
Genome-wide association study identifies five new breast cancer susceptibility loci.
СтатьяПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Turnbull Clare, Ahmed Shahana, Morrison Jonathan, Pernet David, Renwick Anthony, Maranian Mel, Seal Sheila, Ghoussaini Maya, Hines Sarah, Healey Catherine S, Hughes Deborah, Warren-Perry Margaret, Tapper William, Eccles Diana, Evans D Gareth, Breast Cancer Susceptibility Collaboration (UK), Hooning Maartje, Schutte Mieke, van den Ouweland Ans, Houlston Richard, Ross Gillian, Langford Cordelia, Pharoah Paul D P, Stratton Michael R, Dunning Alison M, Rahman Nazneen, Easton Douglas F
Аннотация
Breast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a genome-wide association study in which 582,886 SNPs were genotyped in 3,659 cases with a family history of the disease and 4,897 controls. Promising associations were evaluated in a second stage, comprising 12,576 cases and 12,223 controls. We identified five new susceptibility loci, on chromosomes 9, 10 and 11 (P = 4.6 x 10(-7) to P = 3.2 x 10(-15)). We also identified SNPs in the 6q25.1 (rs3757318, P = 2.9 x 10(-6)), 8q24 (rs1562430, P = 5.8 x 10(-7)) and LSP1 (rs909116, P = 7.3 x 10(-7)) regions that showed more significant association with risk than those reported previously. Previously identified breast cancer susceptibility loci were also found to show larger effect sizes in this study of familial breast cancer cases than in previous population-based studies, consistent with polygenic susceptibility to the disease.