Effect of theophylline F2-alpha-induced contractile activity of the uterus.

Prostaglandins are now extensively used for abortions and for inducing labour in all three trimesters of pregnancy. Owing to the side-effects associated with parenteral administration, preference is now given to local application. This, however, may also give rise to an extreme or inadequate stimulation of the uterus. Therefore, therapeutic procedures capable of effectively influencing exogenous PGF2-alpha-induced uterine contractions and even spontaneous hyperergic uterine contractions are of clinical importance. Theoretically, methylxanthine derivatives may be used in view of their well-known smooth muscle relaxant effect.