Медицинская библиотека · Japanese journal of clinical oncology · 1999

Genetic instability did not lead to p53 mutations in an extremely early-onset breast cancer in a cancer-prone family.

Ishikawa T, Ikeda I, Momiyama N, Yamaoka H, Ishiyama A, Chishima T, Ichikawa Y, Kitamura H, Shuin T, Shimada H

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Аннотация

BACKGROUND

A positive family history is a major contributor to risk of development of breast cancer.

METHODS

Somatic and germ line mutations of p53 and genetic instability were evaluated for an extremely early-onset breast cancer case in a cancer-prone family.

RESULTS

The mode of inheritance in this case was clearly autosomal dominant. DNA replication error was recognized by detecting microsatellite allelic alterations. However, mutations of p53 were not found at either somatic or germ-line level.

CONCLUSION

These genetic studies suggest that an increased genetic instability did not lead to p53 gene mutations in this breast cancer patient.

Для цитирования: Ishikawa T, Ikeda I, Momiyama N, Yamaoka H, Ishiyama A, Chishima T, Ichikawa Y, Kitamura H, Shuin T, Shimada H. Genetic instability did not lead to p53 mutations in an extremely early-onset breast cancer in a cancer-prone family.. Japanese journal of clinical oncology. 1999. DOI: 10.1093/jjco/29.7.332.

Предметные рубрики MeSH

Adult Age of Onset Breast Neoplasms DNA Replication Female Genetic Predisposition to Disease Germ-Line Mutation Humans Immunoenzyme Techniques Microsatellite Repeats Mutation Pedigree Polymorphism, Single-Stranded Conformational Risk Factors Tumor Suppressor Protein p53

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