Strain-Adaptive Micro-Wrinkled Carbon Films Enable Flexible High-Fidelity Intelligent Health Monitoring.

Wrinkled microstructures provide an effective strategy for constructing stable and low-noise soft bioelectronic interfaces, yet their large-area, continuous, and controllable fabrication remains challenging. Here, we report a large-area continuous ultrathin micro-wrinkled film that rapidly forms wrinkle microstructures through interfacial stress instability at a rate of 70 µm·s-1. The film exhibits excellent geometric deformability and mechanical compliance, enabling effective relaxation of local stress concentration at dynamic interfaces. Flexible strain sensors based on this microstructure achieve sensitive and rapid responses over a broad strain adaptability, with a detection range from 23 to 2350 µε and a response time as low as 50 ms, allowing stable monitoring of diverse physiological signals, including pulse, respiration, voice, and muscle motion. Furthermore, owing to its good biocompatibility and conformal contact capability, the film can function as a cardiac interface for high-fidelity cardiac mechanical activity acquisition and electrical regulation of arrhythmia. Building on this platform, we further integrated flexible signal acquisition hardware with machine-learning algorithms to establish a skin-brain inspired intelligent sensing system capable of real-time physiological signal analysis and high-accuracy classification. This work provides a general strategy for developing stable and highly biocompatible next-generation bioelectronic interfaces.