Radiation Fibrosis Syndrome: A Case-Based Approach to Identification, Evaluation, and Treatment.

Radiation fibrosis (RF) is the insidious tissue damage caused by radiation therapy. RF syndrome (RFS) describes the clinical manifestations resulting from RF. Every body system in or traversing the radiation field can be affecting including all neural structures (brain, spinal cord, nerve root, plexus, peripheral nerve, and muscle) and visceral structures (heart, lung, gastrointestinal [GI], etc.). Accurate and comprehensive identification and evaluation of RFS is key to optimizing rehabilitative interventions and maximizing the survivors' function and quality of life.