Bulletin of experimental biology and medicine · 2026
Neurotrophic and Neuroprotective Effects of Magnesium Chelidonate and Chelidonic Acid in Cell Culture Experiments.
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Kozin S V, Kravtsov A A, Moiseev A V, Rubailo A D, Bobrovnik S V, Vasilevskaya E R, Trofimenko A I, Lyasota O M
Аннотация
The neuroprotective and neurotrophic properties of magnesium chelidonate and chelidonic acid at concentrations of 0.01 and 0.1 mM were studied. It was found that magnesium chelidonate and chelidonic acid significantly reduced cell death in primary rat cerebellar neuroglial cultures, both in a model of glutamate excitotoxicity and under conditions of oxygen-glucose deprivation. Both substances exerted a stimulatory effect on the neurotrophic processes in chicken embryo dorsal root ganglion cultures. The neuroprotective and neurotrophic effects of the tested compounds were more pronounced at a concentration of 0.01 mM. In our experiments, magnesium salt of chelidonic acid produced more potent neuroprotective and neurotrophic effects on the studied cultures than chelidonic acid.