Hematology/oncology and stem cell therapy · 2016
Central nervous system infection following allogeneic hematopoietic stem cell transplantation.
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Hanajiri Ryo, Kobayashi Takeshi, Yoshioka Kosuke, Watanabe Daisuke, Watakabe Kyoko, Murata Yutaka, Hagino Takeshi, Seno Yasushi, Najima Yuho, Igarashi Aiko, Doki Noriko, Kakihana Kazuhiko, Sakamaki Hisashi, Ohashi Kazuteru
Аннотация
OBJECTIVE/BACKGROUND: Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years.
METHODS: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection.
RESULTS: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10-1028 days) after allo-HSCT. Causative pathogens were human herpesvirus-6 (n=6), enterococcus (n=2), staphylococcus (n=2), streptococcus (n=2), varicella zoster virus (n=1), cytomegalovirus (n=1), John Cunningham virus (n=1), adenovirus (n=1), and Toxoplasma gondii (n=1). The cumulative incidence of CNS infection was 4.1% at 1 year and 5.5% at 5 years.
CONCLUSION: Multivariate analysis revealed that high-risk disease status was a risk factor for developing CNS infection (p=.02), and that overall survival at 3 years after allo-HSCT was 33% in patients with CNS infection and 53% in those without CNS infection (p=.04).
METHODS: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection.
RESULTS: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10-1028 days) after allo-HSCT. Causative pathogens were human herpesvirus-6 (n=6), enterococcus (n=2), staphylococcus (n=2), streptococcus (n=2), varicella zoster virus (n=1), cytomegalovirus (n=1), John Cunningham virus (n=1), adenovirus (n=1), and Toxoplasma gondii (n=1). The cumulative incidence of CNS infection was 4.1% at 1 year and 5.5% at 5 years.
CONCLUSION: Multivariate analysis revealed that high-risk disease status was a risk factor for developing CNS infection (p=.02), and that overall survival at 3 years after allo-HSCT was 33% in patients with CNS infection and 53% in those without CNS infection (p=.04).
Предметные рубрики MeSH
AdolescentAdultAgedBacterial InfectionsCentral Nervous System InfectionsCytomegalovirusFemaleHematopoietic Stem Cell TransplantationHerpesvirus 6, HumanHumansIncidenceMaleMiddle AgedMultivariate AnalysisRetrospective StudiesRisk FactorsStaphylococcusSurvival RateTransplantation, HomologousVirus DiseasesYoung Adult