Influence of light exposure during early life on the age of onset of bipolar disorder.
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Bauer Michael, Glenn Tasha, Alda Martin, Andreassen Ole A, Angelopoulos Elias, Ardau Raffaella, Baethge Christopher, Bauer Rita, Baune Bernhard T, Bellivier Frank, Belmaker Robert H, Berk Michael, Bjella Thomas D, Bossini Letizia, Bersudsky Yuly, Wo Cheung Eric Yat, Conell Jörn, Del Zompo Maria, Dodd Seetal, Etain Bruno, Fagiolini Andrea, Frye Mark A, Fountoulakis Kostas N, Garneau-Fournier Jade, Gonzalez-Pinto Ana, Gottlieb John F, Harima Hirohiko, Hassel Stefanie, Henry Chantal, Iacovides Apostolos, Isometsä Erkki T, Kapczinski Flávio, Kliwicki Sebastian, König Barbara, Krogh Rikke, Kunz Mauricio, Lafer Beny, Larsen Erik R, Lewitzka Ute, Lopez-Jaramillo Carlos, MacQueen Glenda, Manchia Mirko, Marsh Wendy, Martinez-Cengotitabengoa Mónica, Melle Ingrid, Monteith Scott, Morken Gunnar, Munoz Rodrigo, Nery Fabiano G, O'Donovan Claire, Osher Yamima, Pfennig Andrea, Quiroz Danilo, Ramesar Raj, Rasgon Natalie, Reif Andreas, Ritter Philipp, Rybakowski Janusz K, Sagduyu Kemal, Miranda-Scippa Ângela, Severus Emanuel, Simhandl Christian, Stein Dan J, Strejilevich Sergio, Sulaiman Ahmad Hatim, Suominen Kirsi, Tagata Hiromi, Tatebayashi Yoshitaka, Torrent Carla, Vieta Eduard, Viswanath Biju, Wanchoo Mihir J, Zetin Mark, Whybrow Peter C
Аннотация
METHODS: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 41.3 S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation.
RESULTS: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model.
CONCLUSIONS: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.