Zhonghua yi xue za zhi · 2003
[The relationship of apolipoprotein H gene polymorphism with stroke].
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Xia Jian, Yang Qi-dong, Yang Qi-ming, Xu Hong-wei, Zhang Le
Аннотация
OBJECTIVE: To study the association between apolipoprotein H (apoH) gene polymorphism and cerebral apoplexy among the Hans in Changsha, Hunan Province.
METHODS: Polymorphisms in exon 3 of apoH gene was determined by PCR-single strand conformation polymorphism (PCR-SSCP) analysis and DNA sequencing among 260 patients with stroke of Han nationality in Changsha, including 130 cerebral hemorrhage (CH) patients, of which 50 were with a family history of CH, and 79 with hypertension and 51 without hypertension, and 130 cerebral infarction (CI) patients, of which 50 were with a family history of CI, and 66 with hypertension and 64 without hypertension; 20 members of stroke pedigrees, and 100 healthy controls.
RESULTS: G341A (Ser88Asn) polymorphism in exon 3 of apoH gene was found in Changsha Hans. The frequency of A allele was 0.127 in the CH group, especially in CH patients with a family history of stroke or hypertension, significantly higher than that in control group (0.055, P < 0.05). The frequency of A allele was also significantly higher in members of CH pedigrees than in controls. No association between G341A (Ser88Asn) polymorphism and CI was found.
CONCLUSION: A allele in G341A (Ser88Asn) polymorphism may be a genetic risk factor of CH among Changsha Hans, especially the CH patients with hypertension and those with a family history of hypertension.
METHODS: Polymorphisms in exon 3 of apoH gene was determined by PCR-single strand conformation polymorphism (PCR-SSCP) analysis and DNA sequencing among 260 patients with stroke of Han nationality in Changsha, including 130 cerebral hemorrhage (CH) patients, of which 50 were with a family history of CH, and 79 with hypertension and 51 without hypertension, and 130 cerebral infarction (CI) patients, of which 50 were with a family history of CI, and 66 with hypertension and 64 without hypertension; 20 members of stroke pedigrees, and 100 healthy controls.
RESULTS: G341A (Ser88Asn) polymorphism in exon 3 of apoH gene was found in Changsha Hans. The frequency of A allele was 0.127 in the CH group, especially in CH patients with a family history of stroke or hypertension, significantly higher than that in control group (0.055, P < 0.05). The frequency of A allele was also significantly higher in members of CH pedigrees than in controls. No association between G341A (Ser88Asn) polymorphism and CI was found.
CONCLUSION: A allele in G341A (Ser88Asn) polymorphism may be a genetic risk factor of CH among Changsha Hans, especially the CH patients with hypertension and those with a family history of hypertension.