Cerebrovascular diseases (Basel, Switzerland) · 2002
Atherothrombotic risk factors in subjects with a family history of stroke.
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Lansbury Alastair J, Grant Peter J, Catto Andrew J
Аннотация
BACKGROUND: Subjects with stroke in a first-degree relative are at increased risk of atherothrombotic vascular disease. We aimed to examine atherothrombotic risk factors in such a population.
METHODS: 145 subjects with a first-degree relative with stroke and 143 controls were recruited. Measurements were made of features of the insulin resistance syndrome, haemostatic and fibrinolytic risk factors, and glucose tolerance tests.
RESULTS: The relatives had higher systolic blood pressure, HDL, 2-hour glucose, factor VII:C, fibrinogen, vWF and more had smoked. Differences remained in factor VII:C, systolic BP and 2-hour glucose after adjustment.
CONCLUSIONS: This population demonstrates adverse thrombotic risk factors and increased FVII:C activity may contribute to increased cardiovascular risk.
METHODS: 145 subjects with a first-degree relative with stroke and 143 controls were recruited. Measurements were made of features of the insulin resistance syndrome, haemostatic and fibrinolytic risk factors, and glucose tolerance tests.
RESULTS: The relatives had higher systolic blood pressure, HDL, 2-hour glucose, factor VII:C, fibrinogen, vWF and more had smoked. Differences remained in factor VII:C, systolic BP and 2-hour glucose after adjustment.
CONCLUSIONS: This population demonstrates adverse thrombotic risk factors and increased FVII:C activity may contribute to increased cardiovascular risk.