Journal of occupational and environmental medicine · 2026
The Relation Between Pulmonary Functions and Serum Biomarkers of Lung Diseases Among Workers Exposed to Calcium Carbonate.
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Mourad Basma Hussein, Teleb Hebatallah Saad
Аннотация
OBJECTIVE: This study aimed to examine the association between pulmonary function and serum biomarkers among Egyptian workers occupationally exposed to ultrafine calcium carbonate (CaCO 3 ) particles, which can penetrate biological membranes and accumulate in the lungs.
METHODS: A cross-sectional study was conducted on 80 nonsmoking males: 40 CaCO 3 -exposed workers and 40 matched controls. Participants underwent medical and occupational history taking, clinical examination, spirometry, and serum biomarker measurement (Clara cell protein 16 [CC16], matrix metalloproteinase-9 [MMP-9], and tissue inhibitor of metalloproteinase-1 [TIMP-1]).
RESULTS: Exposed workers demonstrated a significantly higher prevalence of respiratory symptoms along with significantly reduced pulmonary function indices. They also showed decreased CC16 and elevated MMP-9 and TIMP-1 levels. Biomarkers correlated with lung function decline and exposure duration.
CONCLUSIONS: Chronic CaCO 3 exposure was associated with increased respiratory risk, necessitating protective workplace measures.
METHODS: A cross-sectional study was conducted on 80 nonsmoking males: 40 CaCO 3 -exposed workers and 40 matched controls. Participants underwent medical and occupational history taking, clinical examination, spirometry, and serum biomarker measurement (Clara cell protein 16 [CC16], matrix metalloproteinase-9 [MMP-9], and tissue inhibitor of metalloproteinase-1 [TIMP-1]).
RESULTS: Exposed workers demonstrated a significantly higher prevalence of respiratory symptoms along with significantly reduced pulmonary function indices. They also showed decreased CC16 and elevated MMP-9 and TIMP-1 levels. Biomarkers correlated with lung function decline and exposure duration.
CONCLUSIONS: Chronic CaCO 3 exposure was associated with increased respiratory risk, necessitating protective workplace measures.
Предметные рубрики MeSH
HumansMaleCalcium CarbonateOccupational ExposureBiomarkersCross-Sectional StudiesAdultLung DiseasesTissue Inhibitor of Metalloproteinase-1Matrix Metalloproteinase 9Middle AgedUteroglobinEgyptOccupational DiseasesRespiratory Function TestsSpirometryCase-Control StudiesLungAir Pollutants, Occupational