[Etiological work-up for chronic pancreatitis].

The first etiology of chronic pancreatitis is excessive alcohol consumption, which accounts for 46% of causes in the USA. Other include metabolic, genetic, obstructive or autoimmune mechanisms. In 2/3 of cases, several factors are interrelated, and it is essential to investigate the etiology to interrupt, if possible, the natural course of progression to chronic pancreatitis. The initial etiological approach should include detailed questioning, a physical examination, an initial laboratory work-up and cross-sectional imaging (CTscan and MRI). Genetic analysis is indicated if the cause remains uncertain, if the patient has a family history of pancreatic disease, in cases of recurrent pancreatitis or if the patient is young (under 35).