Current medical research and opinion · 2025
Profiles and diagnostic patterns of colorectal cancers among 602 patients attending a tertiary care center in Saudi Arabia for suspected colic disease.
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Said Kamaleldin B, Alshammari Khalid F, Ahmed Ruba M Elsaid, Zakout Yosef M-A, Moursi Soha A, Binsaleh Naif K, Alshammary Fahad M, Alotaibi Arwa A, Alzugahibi Mohammad S, Alshammari Manal A, Alfouzan Fayez R, AlNajib AlFatih M A, Alshammari Amal D, Osman Nutilla A, Alshammary Nafea A, Alshammri Mutlaq S
Аннотация
OBJECTIVES: Owing to the peaking rates and the multifaceted nature of colorectal cancers (CRC), understanding regional epidemiology and clinicopathological characteristics is critical. However, for the severe paucity in high-quality region-specific data, we aimed to determine the prevalence, distribution across age-gender, and identify common gastrointestinal pathological-features, and associations between patients' clinical-histories, definitive-diagnostic findings, and demographic-characteristics.
METHODS: We retrospectively examined records of 602 patients (January 2020-December 2024). Data included demographics, diagnoses (e.g. adenocarcinoma, tubulovillous adenoma with dysplasia [TVA], dysplasia, chronic active colitis, no malignancy, polyps, or differential diagnosis), biopsy-type, and relevant clinical history. Descriptive statistics and inferential tests such as Chi-square and Mann-Whitney U were used.
RESULTS: The cohort was 59.3% (n = 357) male and 40.7% (n = 245) female. Adenocarcinoma increased with age, peaking at 50-69 (53.0%) and females 70-89 (84.2%). TVA was prominent in males (30-49; 28.0%) and females (50-69; 36.1%). Overall, males had higher-frequencies of both adenocarcinoma (n = 137 vs. 95) and TVA (n = 73 vs. 59) compared to females. Rectosigmoid-biopsy was the most common method for diagnosing adenocarcinoma (42.4%), whereas colon-biopsy was more frequent for TVA (27.1%). The highest proportion of "No malignancy" diagnosis was in the 15-29 years age group (males: 65.4%, females: 64.7%). Clinical histories indicating "colon-tumor or polyps" were strongly associated with adenocarcinoma (47.0%) and TVA (30.3%). Significant associations were found between diagnosis and specimen-type and clinical-history and diagnosis.
CONCLUSIONS: This study highlights distinct age- and-gender-specific CRCs-patterns; particularly, prevalence of neoplastic-conditions in elderly with more frequent adenocarcinomas in males and variance of biopsy-sites by diagnosis. These support targeted-screening where more effective diagnostic and early treatment strategies are imperative in-line with the country's 2030-vision and UN's-Sustainable Development Goals-3.
METHODS: We retrospectively examined records of 602 patients (January 2020-December 2024). Data included demographics, diagnoses (e.g. adenocarcinoma, tubulovillous adenoma with dysplasia [TVA], dysplasia, chronic active colitis, no malignancy, polyps, or differential diagnosis), biopsy-type, and relevant clinical history. Descriptive statistics and inferential tests such as Chi-square and Mann-Whitney U were used.
RESULTS: The cohort was 59.3% (n = 357) male and 40.7% (n = 245) female. Adenocarcinoma increased with age, peaking at 50-69 (53.0%) and females 70-89 (84.2%). TVA was prominent in males (30-49; 28.0%) and females (50-69; 36.1%). Overall, males had higher-frequencies of both adenocarcinoma (n = 137 vs. 95) and TVA (n = 73 vs. 59) compared to females. Rectosigmoid-biopsy was the most common method for diagnosing adenocarcinoma (42.4%), whereas colon-biopsy was more frequent for TVA (27.1%). The highest proportion of "No malignancy" diagnosis was in the 15-29 years age group (males: 65.4%, females: 64.7%). Clinical histories indicating "colon-tumor or polyps" were strongly associated with adenocarcinoma (47.0%) and TVA (30.3%). Significant associations were found between diagnosis and specimen-type and clinical-history and diagnosis.
CONCLUSIONS: This study highlights distinct age- and-gender-specific CRCs-patterns; particularly, prevalence of neoplastic-conditions in elderly with more frequent adenocarcinomas in males and variance of biopsy-sites by diagnosis. These support targeted-screening where more effective diagnostic and early treatment strategies are imperative in-line with the country's 2030-vision and UN's-Sustainable Development Goals-3.