Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
Performance of Fecal Immunochemical Test in Individuals With Personal History of Polyps and Family History of Colorectal Cancer: A Systematic Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Karna Rahul, Bilal Mohammad, Nayfeh Tarek, Beran Azizullah, Paladiya Ruchir, Khataniar Himsikhar, Ranganatha Ravishankar, Theis-Mahon Nicole, Gupta Samir, Shaukat Aasma
Аннотация
BACKGROUND & AIMS: There is limited information regarding performance of fecal immunochemical test (FIT) in post-polypectomy surveillance, or for screening individuals with a family history of colorectal cancer (CRC). We conducted a systematic review to assess current evidence regarding diagnostic performance of one time FIT in increased risk populations.
METHODS: A comprehensive search of multiple databases was conducted to assess studies reporting performance of a one-time FIT as screening or surveillance tool in individuals at increased risk of CRC.
RESULTS: We identified 3 studies reporting on 8817 individuals with personal history of polyps who underwent FIT testing. For CRC detection, one-time FIT showed sensitivity ranging from 27.6% to 100.0% and specificity ranging from 55.9% to 94.1% with variable test thresholds and index polyp histology. We identified 12 studies reporting on 5525 individuals with family history of CRC. One-time FIT showed a sensitivity ranging from 25.0% to 100.0% and specificity ranging from 83.1% to 92.0%, with variable test thresholds and family history characteristics.
CONCLUSIONS: Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow-up after polypectomy.
METHODS: A comprehensive search of multiple databases was conducted to assess studies reporting performance of a one-time FIT as screening or surveillance tool in individuals at increased risk of CRC.
RESULTS: We identified 3 studies reporting on 8817 individuals with personal history of polyps who underwent FIT testing. For CRC detection, one-time FIT showed sensitivity ranging from 27.6% to 100.0% and specificity ranging from 55.9% to 94.1% with variable test thresholds and index polyp histology. We identified 12 studies reporting on 5525 individuals with family history of CRC. One-time FIT showed a sensitivity ranging from 25.0% to 100.0% and specificity ranging from 83.1% to 92.0%, with variable test thresholds and family history characteristics.
CONCLUSIONS: Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow-up after polypectomy.