Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study.
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Eder Piotr, Verstock Bram, Culver Emma, Dragoni Gabriele, Kredel Lea Isabell, Wypych Joanna, de Paredes Ana Garcia Garcia, Kaniewska Magdalena, Leibovitzh Haim, Lobaton Triana, Truyens Marie, Oracz Grzegorz, Ribaldone Davide Giuseppe, Starzyńska Teresa, Badaoui Abdenor, Rahier Jean-Francois, Bezzio Cristina, Bossuyt Peter, Falloon Katherine, Pugliese Daniela, Frakes Vozzo Catherine, Jess Tine, Larsen Lone, Olesen Søren Schou, Pal Partha, Chaparro María, Dror Dikla, Ellul Pierre, Gromny Iga, Janiak Maria, Maciejewska Katarzyna, Peleg Noam, Bar-Gil Shitrit Ariella, Szwed Łukasz, Talar-Wojnarowska Renata, Snir Yifat, Weisshof Roni, Zittan Eran, Miechowicz Izabela, Goren Idan
Аннотация
METHODS: An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases of AIP diagnosed in patients with IBD. Complicated AIP was defined as a composite of endocrine and/or exocrine pancreatic insufficiency, and/or pancreatic cancer. We explored factors associated with complicated AIP in IBD.
RESULTS: We included 96 patients [53% males, 79% ulcerative colitis, 72% type 2 AIP, age at AIP diagnosis 35 ± 16 years]. The majority of Crohn's disease [CD] cases [78%] had colonic/ileocolonic involvement. In 59%, IBD preceded AIP diagnosis, whereas 18% were diagnosed simultaneously. Advanced therapy to control IBD was used in 61% and 17% underwent IBD-related surgery. In total, 82% of patients were treated with steroids for AIP, the majority of whom [91%] responded to a single course of treatment. During a mean follow-up of 7 years, AIP complications occurred in 25/96 [26%] individuals. In a multivariate model, older age at AIP diagnosis was associated with a complicated AIP course (odds ratio [OR] = 1.05, p = 0.008), whereas family history of IBD [OR = 0.1, p = 0.03], and CD diagnosis [OR = 0.2, p = 0.04] decreased the risk of AIP complications. No IBD- or AIP-related deaths occurred.
CONCLUSIONS: In this large international cohort of patients with concomitant AIP-IBD, most patients have type 2 AIP and colonic IBD. AIP course is relatively benign and long-term outcomes are favourable, but one-quarter develop pancreatic complications. Age, familial history of IBD, and CD may predict uncomplicated AIP course.