Influence of ethnic origin on the incidence of keratoconus and associated atopic disease in Asian and white patients.
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Daca-Alvarez Maria, Martí Marc, Spinelli Antonino, de Miranda Noel F F C, Palles Claire, Vivas Alfredo, Lachtford Andrew, Monahan Kevin, Szczepkowski Marek, Tarnowski Wieslaw, Makkai-Popa Silviu-Tiberiu, Vidal Rosario, López Irene, Hurtado Elena, Jiménez Fernando, Jiménez-Toscano Marta, Álvaro Edurne, Sanz Gonzalo, Ballestero Araceli, Melone Sirio, Brandáriz Lorena, Prieto Isabel, García-Olmo Damián, Ocaña Teresa, Moreira Rebeca, Moreno Lorena, Carballal Sabela, Moreira Leticia, Pellisé Maria, González-Sarmiento Rogelio, Holowatyj Andreana N, Perea José, Balaguer Francesc, GEOCODE and SECOC consortia
Аннотация
METHODS: This was a retrospective multicentre European study of patients with non-hereditary EOCRC. The impact of the European Society of Gastrointestinal Endoscopy (ESGE), U.S. Multi-Society Task Force (USMSTF), and National Comprehensive Cancer Network (NCCN) guidelines on prevention and early diagnosis was compared. Colorectal cancer was defined as potentially preventable if surveillance colonoscopy would have been performed at least 5 years before the age of diagnosis of colorectal cancer, and diagnosed early if colonoscopy was undertaken between 1 and 4 years before the diagnosis.
RESULTS: Some 903 patients with EOCRC were included. Criteria for familial colorectal cancer risk in ESGE, USMSTF, and NCCN guidelines were met in 6.3, 9.4, and 30.4 per cent of patients respectively. Based on ESGE, USMSTF, and NCCN guidelines, colorectal cancer could potentially have been prevented in 41, 55, and 30.3 per cent of patients, and diagnosed earlier in 11, 14, and 21.1 per cent respectively. In ESGE guidelines, if surveillance had started 10 years before the youngest relative, there would be a significant increase in prevention (41 versus 55 per cent; P = 0.010).
CONCLUSION: ESGE, USMSTF, and NCCN criteria for familial colorectal cancer were met in 6.3, 9.4, and 30.4 per cent of patients with EOCRC respectively. In these patients, early detection and/or prevention could be achieved in 52, 70, and 51.4 per cent respectively. Early and accurate identification of familial colorectal cancer risk and increase in the uptake of early colonoscopy are key to decreasing familial EOCRC.