Evidence-based complementary and alternative medicine : eCAM · 2015
Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825).
СтатьяНазвание и аннотация: Перевод в очереди
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Santos Israel J M, Leite Gerlânia O, Costa José Galberto M, Alves Romulo R N, Campos Adriana R, Menezes Irwin R A, Freita Francisco Ronaldo V, Nunes Maria Janeth H, Almeida Waltécio O
Аннотация
Tropidurus hispidus has been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity of Tropidurus hispidus fat in treating ear edema in an animal model. Oil from T. hispidus (OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region of Tropidurus hispidus using hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH.