Nippon Ganka Gakkai zasshi · 2010
[Mechanism of blurred vision after brinzolamide instillation].
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Noguchi Tsuyoshi, Kawasaki Shiro, Mizoue Shiro, Yamaguchi Masahiko, Ohashi Yuichi
Аннотация
PURPOSE: Eye drops of carbonic anhydrase inhibitor (Brinzolamide) are known to case blurred vision after instillation. Using tear film stability analysis system (TSAS) and functional visual acuity measurement (FVAM) we studied the mechanism of blurred vision.
METHODS: Ten healthy volunteers were studied. Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes after 1 minutes eye-closure after instillation the breakup index (BUI) of TSAS and FVAM were measured.
RESULTS: Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes since 1 minutes eye-closure after instillation the BUI of TSAS was 88.3 +/- 1.2, 38.5 +/- 7, 72.1 +/- 4.2, 78.8 +/- 5.1, 83.7 +/- 2.2 respectively, and the FVAM was 1.013 +/- 0.0047, 0.925 +/- 0.029, 1 +/- 0.0075, 1.007 +/- 0.0072, 1.015 +/- 0.0052 respectively. Immediately after 1 minutes eye-closure both BUI and FVAM were low. From 3 minutes after instillation both BUI and FVAM recovered.
CONCLUSIONS: It is suggested that blurred vision after instillation of brinzolamide 1% is associated with the unstableness of tear film. Analyses by TSAS and FVAM are useful to determine both the vision improvement and pharmacokinetics after instillation.
METHODS: Ten healthy volunteers were studied. Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes after 1 minutes eye-closure after instillation the breakup index (BUI) of TSAS and FVAM were measured.
RESULTS: Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes since 1 minutes eye-closure after instillation the BUI of TSAS was 88.3 +/- 1.2, 38.5 +/- 7, 72.1 +/- 4.2, 78.8 +/- 5.1, 83.7 +/- 2.2 respectively, and the FVAM was 1.013 +/- 0.0047, 0.925 +/- 0.029, 1 +/- 0.0075, 1.007 +/- 0.0072, 1.015 +/- 0.0052 respectively. Immediately after 1 minutes eye-closure both BUI and FVAM were low. From 3 minutes after instillation both BUI and FVAM recovered.
CONCLUSIONS: It is suggested that blurred vision after instillation of brinzolamide 1% is associated with the unstableness of tear film. Analyses by TSAS and FVAM are useful to determine both the vision improvement and pharmacokinetics after instillation.