Internal medicine (Tokyo, Japan) · 2016
Over-the-counter Drug Induced Autoimmune Hepatitis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Takeda Karin, Oda Masaya, Okada Takemichi, Yamazaki Hitoshi, Ohbu Makoto, Watanabe Masaaki, Yokomori Hiroaki
Аннотация
A 64-year-old man seeking treatment for a common cold was admitted to our hospital due to symptoms of general fatigue and liver dysfunction. A thorough history review revealed that the patient had recently started taking an over-the-counter (OTC) drug. Drug-induced lymphocyte stimulation tests were positive. Serum markers for autoimmune hepatitis (AIH) were particularly elevated. Liver biopsy revealed spotty necrosis and ceroid-pigmented Kupffer cells and piecemeal necrosis with multiple plasma cells. He responded to corticosteroids, thus suggesting the presence of an immune-mediated component associated with the liver injury. Liver injury after using OTCs should be included in the differential diagnosis for chronic hepatitis with features of AIH.