Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 1997
[Ocular pulse amplitude and local carbonic anhydrase inhibition].
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Schmidt K G, Dick B, von Rückmann A, Pillunat L E
Аннотация
UNLABELLED: Ocular perfusion is increasingly being discussed in the pathogenesis of glaucoma. The present study was designed to investigate ocular pulse amplitude (OPA) in primary open-angle glaucoma (POAG) patients with elevated intraocular pressure (HTG) and non-glaucomatous controls (CTL) following topical application of the carbonic anhydrase inhibitor dorzolamide.
METHODS: OPA (Ocular Blood Flow System, OBF Labs UK) intraocular pressure (IOP), heart rate (HR), and systolic (BPsyst) and diastolic (BPdiast) bronchial artery pressures were measured before and 2 days after initiating treatment in 33 cataract patients with n = 14) and without (n = 19) POAG.
RESULTS: Following application of dorzolamide, IOP (mmHg) in drug-treated HTG and CTL eyes was highly significantly reduced (p < 0.001) and in vehicle-treated HTG and CTL eyes significantly reduced (p < 0.03) compared to respective baseline measurements. OPA (mmHg) in drug-treated HTG and CTL eyes was significantly increased (p < 0.05) and in vehicle-treated eyes in affected compared to respective baseline measurements. Systemic perfusion parameters were also unchanged.
CONCLUSION: Dorzolamide increased OPA in HTG and CTL eyes. An increase in OPA may improve the prognosis of HTG.
METHODS: OPA (Ocular Blood Flow System, OBF Labs UK) intraocular pressure (IOP), heart rate (HR), and systolic (BPsyst) and diastolic (BPdiast) bronchial artery pressures were measured before and 2 days after initiating treatment in 33 cataract patients with n = 14) and without (n = 19) POAG.
RESULTS: Following application of dorzolamide, IOP (mmHg) in drug-treated HTG and CTL eyes was highly significantly reduced (p < 0.001) and in vehicle-treated HTG and CTL eyes significantly reduced (p < 0.03) compared to respective baseline measurements. OPA (mmHg) in drug-treated HTG and CTL eyes was significantly increased (p < 0.05) and in vehicle-treated eyes in affected compared to respective baseline measurements. Systemic perfusion parameters were also unchanged.
CONCLUSION: Dorzolamide increased OPA in HTG and CTL eyes. An increase in OPA may improve the prognosis of HTG.