[The hypotensive action and side effects of the carboanhydrase inhibitor dorzolamide hydrochloride].

Effects of a carboanhydrase inhibitor 2% dorsolamine hydrochloride solution (Trusopt) on intraocular pressure and some ocular functions have been studied in patients with primary open-angle glaucoma (POAG): 10 patients aged 56 to 72 (16 eyes) with POAG and 5 patients aged 60 to 68 (8 eyes) with normal ophthalmic tone administered a single instillation of Trusopt and 15 subjects aged 63 to 82 (21 eyes) with POAG to whom Trusopt was administered three times daily for 14 days. A single instillation of the drug resulted in a reliable decrease of intraocular pressure both in glaucoma patients and subjects with normal ophthalmic tone. Maximal lowering of intraocular pressure was recorded 2 hours after instillation, by 21.4% of initial, on average. The hypotensive effect persisted for 12 hours (8.9% reduction of intraocular pressure). 80% of examinees complained of a sensation of short-term burning in the eye directly after instillation. Prolonged use of Trusopt was associated with a tendency to boosting the hypotensive effect: after 12 hours intraocular pressure was 15.4% lower than initially. Tonography showed a reliable (18.5%) reduction of aqueous humor production.