Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2013
[The association of indicators of serum lipids and bile in individuals with the family history, burdened by a bile stone disease].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Grigor'eva I N, Slobodchikova M A
Аннотация
PURPOSE: To evaluate serum and bile lipids levels in persons with and without positive family history of gallstone disease (PFH GSD).
MATERIALS AND METHODS: 165 people were surveyed: 71 people with PFH GSD and 94 persons without PFH GSD. was evaluated: in serum--total cholesterol--TCh, triglycerides--TG, HDL, in the gallbladder bile--cholesterol (BCh), total bile acids (TBA), TBA/BCh coefficient (TBC), sialic (SA) and cholic acid (CA).
RESULTS: TCh (5.3 +/- 0.13 mmol/L), TG (2.1 +/- 0.13 mmol/L) blood serum levels and BCh (3.6 +/- 0.2 g/l) were higher in persons with PFH GSD than in those without PFH GSD (4.8 +/- 0.1; 1.2 +/- 0.09 and 2.8 +/- 0.2, respectively), and HDL (1.0 +/- 0.04 mmol/L) and TBC levels (6.9 +/- 0.5 Units) in persons with PFH GSD were lower than in those without PFH GSD (1.5 +/- 0.03 and 9.3 +/- 0.8, respectively), p < 0.05 in all cases. TBA, SA and CA levels did not differ between two groups.
CONCLUSION: PFH GSD was associated with blood serum lipid profile (total cholesterol, triglycerides, HDL) and the composition of bile (bile cholesterol, TBA/BCh coefficient).
MATERIALS AND METHODS: 165 people were surveyed: 71 people with PFH GSD and 94 persons without PFH GSD. was evaluated: in serum--total cholesterol--TCh, triglycerides--TG, HDL, in the gallbladder bile--cholesterol (BCh), total bile acids (TBA), TBA/BCh coefficient (TBC), sialic (SA) and cholic acid (CA).
RESULTS: TCh (5.3 +/- 0.13 mmol/L), TG (2.1 +/- 0.13 mmol/L) blood serum levels and BCh (3.6 +/- 0.2 g/l) were higher in persons with PFH GSD than in those without PFH GSD (4.8 +/- 0.1; 1.2 +/- 0.09 and 2.8 +/- 0.2, respectively), and HDL (1.0 +/- 0.04 mmol/L) and TBC levels (6.9 +/- 0.5 Units) in persons with PFH GSD were lower than in those without PFH GSD (1.5 +/- 0.03 and 9.3 +/- 0.8, respectively), p < 0.05 in all cases. TBA, SA and CA levels did not differ between two groups.
CONCLUSION: PFH GSD was associated with blood serum lipid profile (total cholesterol, triglycerides, HDL) and the composition of bile (bile cholesterol, TBA/BCh coefficient).