[The association of indicators of serum lipids and bile in individuals with the family history, burdened by a bile stone disease].

PURPOSE: To evaluate serum and bile lipids levels in persons with and without positive family history of gallstone disease (PFH GSD).

MATERIALS AND

METHODS

165 people were surveyed: 71 people with PFH GSD and 94 persons without PFH GSD. was evaluated: in serum--total cholesterol--TCh, triglycerides--TG, HDL, in the gallbladder bile--cholesterol (BCh), total bile acids (TBA), TBA/BCh coefficient (TBC), sialic (SA) and cholic acid (CA).

RESULTS

TCh (5.3 +/- 0.13 mmol/L), TG (2.1 +/- 0.13 mmol/L) blood serum levels and BCh (3.6 +/- 0.2 g/l) were higher in persons with PFH GSD than in those without PFH GSD (4.8 +/- 0.1; 1.2 +/- 0.09 and 2.8 +/- 0.2, respectively), and HDL (1.0 +/- 0.04 mmol/L) and TBC levels (6.9 +/- 0.5 Units) in persons with PFH GSD were lower than in those without PFH GSD (1.5 +/- 0.03 and 9.3 +/- 0.8, respectively), p < 0.05 in all cases. TBA, SA and CA levels did not differ between two groups.

CONCLUSION

PFH GSD was associated with blood serum lipid profile (total cholesterol, triglycerides, HDL) and the composition of bile (bile cholesterol, TBA/BCh coefficient).