Analysis of risk factors associated with precancerous lesion of gastric cancer in patients from eastern China: a comparative study.

PURPOSE: To investigate the association between various risk factors and precancerous lesion of gastric cancer (PLGC) in patients from eastern China.

MATERIALS AND

METHODS

501 cases of PLGC and 523 cases of superficial gastritis were included. A comparative study of the relation between different risk factors and PGLC was performed.

RESULTS

Statistical differences were noted in a series of indexes including Helicobacter pylori (HP) infection, family history of esophageal cancer (EC), gastric cancer (GC) and chronic atrophic gastritis (CAG), a history of CAG, gastric polyps (GP) and gastric ulcer (GU), usage of non-steroids (e.g., aspirin), gastroesophageal reflux disease (GERD), consuming alcohol, eating food rich in nitroso compounds, irregular eating habits with no breakfast, ingestion of smoked meat, fried food and spicy food, anxiety and depression. The risk factors associated with PLGC ranked in an order of a history of CAG, GP, family history of GC, usage of non-steroids (e.g., aspirin), ingestion of spicy food frequently, HP infection, family history of EC, consuming alcohol, anxiety, a history of GU, GERD and family history of CAG.

CONCLUSIONS

A history of CAG was most associated with PLGC in patients from eastern China, followed by a history of GP and family history of GC.