Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
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Elena Joanne W, Steplowski Emily, Yu Kai, Hartge Patricia, Tobias Geoffrey S, Brotzman Michelle J, Chanock Stephen J, Stolzenberg-Solomon Rachael Z, Arslan Alan A, Bueno-de-Mesquita H Bas, Helzlsouer Kathy, Jacobs Eric J, LaCroix Andrea, Petersen Gloria, Zheng Wei, Albanes Demetrius, Allen Naomi E, Amundadottir Laufey, Bao Ying, Boeing Heiner, Boutron-Ruault Marie-Christine, Buring Julie E, Gaziano J Michael, Giovannucci Edward L, Duell Eric J, Hallmans Göran, Howard Barbara V, Hunter David J, Hutchinson Amy, Jacobs Kevin B, Kooperberg Charles, Kraft Peter, Mendelsohn Julie B, Michaud Dominique S, Palli Domenico, Phillips Lawrence S, Overvad Kim, Patel Alpa V, Sansbury Leah, Shu Xiao-Ou, Simon Michael S, Slimani Nadia, Trichopoulos Dimitrios, Visvanathan Kala, Virtamo Jarmo, Wolpin Brian M, Zeleniuch-Jacquotte Anne, Fuchs Charles S, Hoover Robert N, Gross Myron
Аннотация
METHODS: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer.
RESULTS: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52).
CONCLUSIONS: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.