Diseases of the colon and rectum · 2011
Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study.
Клиническое исследование II фазыСравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Crockett Seth D, Long Millie D, Dellon Evan S, Martin Christopher F, Galanko Joseph A, Sandler Robert S
Аннотация
BACKGROUND: The relationship between alcohol intake and rectal cancer is uncertain.
OBJECTIVE: We sought to evaluate whether alcohol consumption is associated with distal colorectal cancer and rectal cancer specifically.
DESIGN: Data on alcohol intake were examined from the North Carolina Colon Cancer Study, a population-based case-control study of distal colorectal cancer.
SETTING: This study encompassed 33 counties in the central and eastern part of North Carolina.
PATIENTS: Cases had adenocarcinoma of the rectum, rectosigmoid, and sigmoid colon. Controls were frequency-matched on age, race, and sex.
INTERVENTIONS: Demographic and dietary intake data were collected with use of a validated questionnaire.
MAIN OUTCOME MEASURES: Logistic regression was used to estimate odds ratios for the relationship between alcohol consumption and distal colorectal cancer.
RESULTS: Included in the study were 1033 cases and 1011 controls. The odds ratio for rectal cancer comparing any vs no alcohol intake was 0.73 (95% CI 0.60, 0.90), adjusted for age, sex, race, smoking status, obesity, education, red meat intake, use of nonsteroidal anti-inflammatory medications, and family history of colorectal cancer. The odds ratio for moderate alcohol (≤14 g/day) was 0.66 (95% CI 0.53, 0.82), whereas the odds ratio for heavy alcohol (>14 g/day) was 0.93 (95% CI 0.70, 1.23). Moderate beer and wine intakes were also inversely associated with distal colorectal cancer: odds ratios 0.76 (95% CI 0.60, 0.96) and 0.69 (95% CI 0.56, 0.86).
LIMITATIONS: This was a retrospective, observational study. Residual confounding is possible.
CONCLUSIONS: In this study, moderate alcohol intake (especially wine) was inversely associated with distal colorectal cancer.
OBJECTIVE: We sought to evaluate whether alcohol consumption is associated with distal colorectal cancer and rectal cancer specifically.
DESIGN: Data on alcohol intake were examined from the North Carolina Colon Cancer Study, a population-based case-control study of distal colorectal cancer.
SETTING: This study encompassed 33 counties in the central and eastern part of North Carolina.
PATIENTS: Cases had adenocarcinoma of the rectum, rectosigmoid, and sigmoid colon. Controls were frequency-matched on age, race, and sex.
INTERVENTIONS: Demographic and dietary intake data were collected with use of a validated questionnaire.
MAIN OUTCOME MEASURES: Logistic regression was used to estimate odds ratios for the relationship between alcohol consumption and distal colorectal cancer.
RESULTS: Included in the study were 1033 cases and 1011 controls. The odds ratio for rectal cancer comparing any vs no alcohol intake was 0.73 (95% CI 0.60, 0.90), adjusted for age, sex, race, smoking status, obesity, education, red meat intake, use of nonsteroidal anti-inflammatory medications, and family history of colorectal cancer. The odds ratio for moderate alcohol (≤14 g/day) was 0.66 (95% CI 0.53, 0.82), whereas the odds ratio for heavy alcohol (>14 g/day) was 0.93 (95% CI 0.70, 1.23). Moderate beer and wine intakes were also inversely associated with distal colorectal cancer: odds ratios 0.76 (95% CI 0.60, 0.96) and 0.69 (95% CI 0.56, 0.86).
LIMITATIONS: This was a retrospective, observational study. Residual confounding is possible.
CONCLUSIONS: In this study, moderate alcohol intake (especially wine) was inversely associated with distal colorectal cancer.