Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2010
Familial pancreatic cancer in Italy. Risk assessment, screening programs and clinical approach: a position paper from the Italian Registry.
СтатьяКлинические рекомендацииНазвание и аннотация: Перевод в очереди
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Del Chiaro Marco, Zerbi Alessandro, Capurso Gabriele, Zamboni Giuseppe, Maisonneuve Patrick, Presciuttini Silvano, Arcidiacono Paolo Giorgio, Calculli Lucia, Falconi Massimo, Italian Registry for Familial Pancreatic Cancer
Аннотация
In Italy, pancreatic cancer is the fifth leading cause of tumor related death with about 7000 new cases per year and a mortality rate of 95%. In a recent prospective epidemiological study on the Italian population, a family history was found in about 10% of patients suffering from a ductal adenocarcinoma of the pancreas (PDAC). A position paper from the Italian Registry for Familial Pancreatic Cancer was made to manage these high-risk individuals. Even though in the majority of high-risk individuals a genetic test to identify familial predisposition is not available, a screening protocol seems to be reasonable for subjects who have a >10-fold greater risk for the development of PDAC. However this kind of screening should be included in clinical trials, performed in centers with high expertise in pancreatic disease, using the least aggressive diagnostic modalities.