Acta oto-laryngologica · 2008
Familial Zenker's diverticulum.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Klockars Tuomas, Sihvo Eero, Mäkitie Antti
Аннотация
CONCLUSION: The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosomal dominant; recessive inheritance is non-existent or extremely rare.
OBJECTIVES: To study the inheritance of Zenker's diverticulum.
SUBJECTS AND METHODS: A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum.
RESULTS: The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.
OBJECTIVES: To study the inheritance of Zenker's diverticulum.
SUBJECTS AND METHODS: A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum.
RESULTS: The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.