Nature clinical practice. Gastroenterology & hepatology · 2008
A case of IgG4-associated cholangitis and autoimmune pancreatitis responsive to corticosteroids.
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Small Aaron J, Loftus Conor G, Smyrk Thomas C, Baron Todd H
Аннотация
BACKGROUND: A 72-year-old male presented to the emergency department with epigastric pain, anorexia and progressive jaundice of 1 week's duration. He had no prior history of gastrointestinal illness, diabetes or cancer. He did not smoke or consume alcohol. He did have a family history of colon and bone cancer.
INVESTIGATIONS: Biochemical and serologic studies, CT scan, abdominal ultrasound, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, biliary cytology, pancreas needle biopsies and immunohistochemical stainings.
DIAGNOSIS: Autoimmune pancreatitis with IgG(4)-associated sclerosing cholangitis affecting the extrahepatic biliary ducts and mimicking primary sclerosing cholangitis and cholangiocarcinoma.
MANAGEMENT: Corticosteroids and immunomodulatory therapy.
INVESTIGATIONS: Biochemical and serologic studies, CT scan, abdominal ultrasound, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, biliary cytology, pancreas needle biopsies and immunohistochemical stainings.
DIAGNOSIS: Autoimmune pancreatitis with IgG(4)-associated sclerosing cholangitis affecting the extrahepatic biliary ducts and mimicking primary sclerosing cholangitis and cholangiocarcinoma.
MANAGEMENT: Corticosteroids and immunomodulatory therapy.