Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2003
Causation of Borrmann type 4 gastric cancer: heritable factors or environmental factors?
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Ying, Yoshimura Kimio, Yamaguchi Naohito, Shinmura Kazuya, Yokota Jun, Katai Hitoshi
Аннотация
BACKGROUND: the prognosis of borrmann type 4 gastric cancer remains poor today. the relative contributions of genetic factors and nongenetic factors to type 4 gastric cancer are unclear. the study of family history and spousal history of cancer may play an important role in the assessment of causation of this severe gastric cancer.
METHODS: during the period 1995-1997, 1118 consecutive patients with histologically confirmed gastric cancer (probands), including 113 with type 4 carcinoma, were admitted to the national cancer center hospital. the type of carcinoma, as well as the family history of cancer in first-degree relatives and spouses of the probands, was abstracted from medical records. family history and spousal history of cancer were compared between type 4 and other types of gastric cancer.
RESULTS: while paternal history had no association with type 4 carcinoma compared with other types, maternal history was associated with a fourfold risk [95% confidence interval (ci), 1.6-9.3] of daughters' type 4 carcinoma, but not sons'. among probands whose wives had a history of gastric cancer, the risks of type 4 gastric cancer were significantly increased, to as high as 13-fold (95% ci, 2.5-65.3). however, husbands' history had no relationship with wives' type 4 carcinoma. no relationship between type 4 carcinoma and family history or spousal history of other cancers was observed.
CONCLUSION: the present study suggested that environmental factors may have a key effect in causing type 4 carcinoma. the findings may be valuable for identifying subjects at high risk of such malignant gastric cancer as borrmann type 4.
METHODS: during the period 1995-1997, 1118 consecutive patients with histologically confirmed gastric cancer (probands), including 113 with type 4 carcinoma, were admitted to the national cancer center hospital. the type of carcinoma, as well as the family history of cancer in first-degree relatives and spouses of the probands, was abstracted from medical records. family history and spousal history of cancer were compared between type 4 and other types of gastric cancer.
RESULTS: while paternal history had no association with type 4 carcinoma compared with other types, maternal history was associated with a fourfold risk [95% confidence interval (ci), 1.6-9.3] of daughters' type 4 carcinoma, but not sons'. among probands whose wives had a history of gastric cancer, the risks of type 4 gastric cancer were significantly increased, to as high as 13-fold (95% ci, 2.5-65.3). however, husbands' history had no relationship with wives' type 4 carcinoma. no relationship between type 4 carcinoma and family history or spousal history of other cancers was observed.
CONCLUSION: the present study suggested that environmental factors may have a key effect in causing type 4 carcinoma. the findings may be valuable for identifying subjects at high risk of such malignant gastric cancer as borrmann type 4.