Acute Posterior Multifocal Placoid Pigment Epitheliopathy-Like Panuveitis Following Mpox Vaccination.

PURPOSE: To report a case of APMPPE-like panuveitis following mpox vaccination.

METHODS

Case report.

RESULTS

A 37-year-old Chinese man presented with bilateral anterior and intermediate uveitis, retinal vasculitis and unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) 2 weeks following JYNNEOS mpox vaccination. Investigations excluded infectious and systemic inflammatory causes. Multi-modal imaging revealed features consistent with APMPPE in the left eye. His symptoms and clinical signs improved with topical and systemic corticosteroid therapy with no recurrence off treatment over a 9-month follow-up.

CONCLUSION

Clinicians should be aware of the possibility of APMPPE-like panuveitis as a rare ocular complication following the mpox vaccine.