The Science of the total environment · 2025
Di-2-ethylhexyl phthalate may exaggerate allergic response in boys with atopic dermatitis - 4-year follow-up of the Taiwan Maternal and Infant Cohort Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lu Chin-Li, Wen Hui-Ju, Wang Chiung-Shiow, Sun Chien-Wen, Wu Ming-Tsang, Chen Mei-Lien, Hsieh Chia-Jung, Wang Shu-Li, TMICS study group
Аннотация
BACKGROUND: Di-2-ethylhexyl phthalate (DEHP) is known for its anti-androgenic effect and has been linked to atopic allergic diseases, with experimental studies suggesting a potential adjuvant role. This study aimed to examine the association between prenatal and postnatal DEHP exposure and early atopic allergic disease in young children.
METHODS: The Taiwan Mothers and Infants Cohort Study (TMICS) enrolled pregnant women and their newborns between 2012 and 2015. DEHP metabolite concentrations in maternal and child urine samples were measured using liquid chromatography-tandem mass spectrometry and expressed as the molar sum (ΣDEHP). Children's atopic dermatitis (AD) was assessed using parental questionnaires, and total immunoglobulin E (tIgE) levels were measured at the age of four. Associations were analyzed using multivariable general linear and binary logistic regression models.
RESULTS: A total of 241 mother-child pairs with complete data were included. Each one-unit increase in the natural logarithm of prenatal ΣDEHP exposure was associated with a higher risk of AD (adjusted odds ratio [AOR]: 1.42, 95 % confidence interval [CI]: 1.01-2.01), particularly in boys and those with a maternal family history of allergies (AOR [95 % CI]: 3.05[1.06-8.74]). Among boys with AD or living in humid environments, a two-fold increase in postnatal ΣDEHP exposure was significantly associated with a 1.23- and 1.28-fold increase in tIgE levels after adjustment for prenatal DEHP and other covariates, respectively.
CONCLUSION: DEHP may exacerbate allergic responses in boys who are already sensitized, indicating a potential adjuvant effect. Therefore, reducing DEHP exposure in high-risk groups is recommended.
METHODS: The Taiwan Mothers and Infants Cohort Study (TMICS) enrolled pregnant women and their newborns between 2012 and 2015. DEHP metabolite concentrations in maternal and child urine samples were measured using liquid chromatography-tandem mass spectrometry and expressed as the molar sum (ΣDEHP). Children's atopic dermatitis (AD) was assessed using parental questionnaires, and total immunoglobulin E (tIgE) levels were measured at the age of four. Associations were analyzed using multivariable general linear and binary logistic regression models.
RESULTS: A total of 241 mother-child pairs with complete data were included. Each one-unit increase in the natural logarithm of prenatal ΣDEHP exposure was associated with a higher risk of AD (adjusted odds ratio [AOR]: 1.42, 95 % confidence interval [CI]: 1.01-2.01), particularly in boys and those with a maternal family history of allergies (AOR [95 % CI]: 3.05[1.06-8.74]). Among boys with AD or living in humid environments, a two-fold increase in postnatal ΣDEHP exposure was significantly associated with a 1.23- and 1.28-fold increase in tIgE levels after adjustment for prenatal DEHP and other covariates, respectively.
CONCLUSION: DEHP may exacerbate allergic responses in boys who are already sensitized, indicating a potential adjuvant effect. Therefore, reducing DEHP exposure in high-risk groups is recommended.