Journal of endodontics · 2011
Cytotoxicity comparison of mineral trioxide aggregates and EndoSequence bioceramic root repair materials.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Damas Beth Ann, Wheater Michelle A, Bringas Josef S, Hoen Michael M
Аннотация
INTRODUCTION: The purpose of this bench top evidence level 5 in vitro study was to compare the cytotoxic effect of 2 brands of white mineral trioxide aggregate cement (ProRoot MTA and MTA-Angelus), Brasseler EndoSequence Root Repair Material, and Brasseler EndoSequence Root Repair Putty by using human dermal fibroblasts.
METHODS: The cells were cultured in recommended culture conditions and exposed to the tested materials. The cytotoxic effects were recorded at an observation period of 24 hours by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-based colorimetric assay. Results were analyzed by using one-way analysis of variance with significance of p < .05.
RESULTS: All materials tested demonstrated cell viability ≥ 91.8%. Overall, there was no statistically significant difference in cell viability of ProRoot MTA, MTA-Angelus, and Brasseler EndoSequence Root Repair Material. However, there was a statistically significant difference negatively associated with the cell viability of human dermal fibroblasts in association with the Brasseler EndoSequence Root Repair Putty.
CONCLUSIONS: The Brasseler EndoSequence Root Repair Materials were shown to have similar cytotoxicity levels to those of ProRoot MTA and MTA-Angelus.
METHODS: The cells were cultured in recommended culture conditions and exposed to the tested materials. The cytotoxic effects were recorded at an observation period of 24 hours by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-based colorimetric assay. Results were analyzed by using one-way analysis of variance with significance of p < .05.
RESULTS: All materials tested demonstrated cell viability ≥ 91.8%. Overall, there was no statistically significant difference in cell viability of ProRoot MTA, MTA-Angelus, and Brasseler EndoSequence Root Repair Material. However, there was a statistically significant difference negatively associated with the cell viability of human dermal fibroblasts in association with the Brasseler EndoSequence Root Repair Putty.
CONCLUSIONS: The Brasseler EndoSequence Root Repair Materials were shown to have similar cytotoxicity levels to those of ProRoot MTA and MTA-Angelus.
Предметные рубрики MeSH
Aluminum CompoundsAnti-Infective Agents, LocalBiocompatible MaterialsCalcium CompoundsCalcium PhosphatesCell DeathCell SurvivalCells, CulturedChlorhexidineColoring AgentsCulture MediaDrug CombinationsFibroblastsHumansMaterials TestingOxidesRoot Canal Filling MaterialsSilicatesSkinTantalumTetrazolium SaltsThiazolesTime FactorsZirconium