International journal of pharmaceutics · 2006
Synthesis and characterization of xylan-coated magnetite microparticles.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Silva Amanda K Andriola, da Silva Erica L, Oliveira Elquio E, Nagashima T, Soares Luiz Alberto L, Medeiros Aldo C, Araújo José H, Araújo Ivonete B, Carriço Artur S, Egito E Sócrates T
Аннотация
This work evaluates an experimental set-up to coat superparamagnetic particles in order to protect them from gastric dissolution. First, magnetic particles were produced by coprecipitation of iron salts in alkaline medium. Afterwards, an emulsification/cross-linking reaction was carried out in order to produce magnetic polymeric particles. The sample characterization was performed by X-ray powder diffraction, laser scattering particle size analysis, optical microscopy, thermogravimetric analysis and vibrating sample magnetometry. In vitro dissolution tests at gastric pH were evaluated for both magnetic particles and magnetic polymeric particles. The characterization data have demonstrated the feasibility of the presented method to coat, and protect magnetite particles from gastric dissolution. Such systems may be very promising for oral administration.