The International journal of prosthodontics · 2003
Cytotoxicity of antimicrobial tissue conditioners containing silver-zeolite.
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Abe Yasuhiko, Ueshige Morikatsu, Takeuchi Maho, Ishii Mie, Akagawa Yasumasa
Аннотация
PURPOSE: The purpose of this study was to determine the effects of incorporating antimicrobial silver-zeolite on the in vitro cytotoxicities of five tissue conditioners against the living dermal model, which consisted of normal human dermal fibroblasts in a collagen lattice.
MATERIALS AND METHODS: Samples of each tissue conditioner containing silver-zeolite (2 wt% and 5 wt%) were prepared; samples without silver-zeolite were used as a control. Cytotoxicity of each sample against the living dermal model was evaluated by cell viability with MTT assay.
RESULTS: Cell viabilities for Visco-Gel, GC Soft-Liner, FITT, and SR-Ivoseal decreased with increasing silver-zeolite content. Cell viability for Shofu Tissue Conditioner showed no significant difference with degree of silver-zeolite incorporation and had higher values than other tissue conditioners.
CONCLUSION: Individual compounds eluted from tissue conditioners and silver ions released from silver-zeolite might cause such cytotoxicity. The results suggest that Shofu Tissue Conditioner is a possible candidate for a novel antimicrobial tissue conditioner containing silver-zeolite because it showed the highest cell viability and the smallest influence of incorporating silver-zeolite.
MATERIALS AND METHODS: Samples of each tissue conditioner containing silver-zeolite (2 wt% and 5 wt%) were prepared; samples without silver-zeolite were used as a control. Cytotoxicity of each sample against the living dermal model was evaluated by cell viability with MTT assay.
RESULTS: Cell viabilities for Visco-Gel, GC Soft-Liner, FITT, and SR-Ivoseal decreased with increasing silver-zeolite content. Cell viability for Shofu Tissue Conditioner showed no significant difference with degree of silver-zeolite incorporation and had higher values than other tissue conditioners.
CONCLUSION: Individual compounds eluted from tissue conditioners and silver ions released from silver-zeolite might cause such cytotoxicity. The results suggest that Shofu Tissue Conditioner is a possible candidate for a novel antimicrobial tissue conditioner containing silver-zeolite because it showed the highest cell viability and the smallest influence of incorporating silver-zeolite.