Interactions of cephalosporins and penicillins with nonpolar macroporous styrenedivinylbenzene copolymers.

The conditions of sorption of penicillins and cephalosporins on nonionic macroporous copolymers of styrenedivinylbenzene were evaluated. By increasing the methanol concentration in the eluent, the sorption decreased. Salts exerted little influence on sorption. However, pH exerted a remarkable effect on sorption, and the capacity factor variations according to the pH are quantitatively described. Some typical separations are shown.