Overcoming Transmission Barriers: A Dual-Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing.

The local inflammatory response and ongoing viral replication caused by monkeypox virus (MPXV) infection pose severe challenges for clinical treatment. Traditional treatment strategies are unable to achieve the dual goals of virus clearance and tissue repair simultaneously. This study innovatively adopts a hierarchical assembly strategy of "mesoporous carrier anchoring-gel matrix embedding" to construct a functionalized hydrogel (Polymer@mPDA@Gel). Using mesoporous polydopamine (mPDA) as the exclusive anchoring site to load the polymer, forming an efficient photothermal component, and then embedding this component in a gel matrix with strong adhesion and good biocompatibility. Through hierarchical assembly, the photothermal performance, anti-inflammatory performance, and biointerfacial properties are precisely integrated to lay the core foundation for its anti-viral and anti-inflammatory functions. The functionalized hydrogel constructed realizes targeted clearance of MPXV, regulation of inflammation, and integration of tissue repair, providing a new material technology path and theoretical support for the clinical treatment of MPXV infection.