Diabetes research and clinical practice · 2006
Gestational diabetes: Validity of ADA and WHO diagnostic criteria using NDDG as the reference test.
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Santos-Ayarzagoitia Magaly, Salinas-Martínez Ana M, Villarreal-Pérez Jesús Z
Аннотация
OBJECTIVE: Evidence is provided to clinicians and decision makers on the validity of ADA and WHO tests based on NDDG criteria for gestational diabetes.
MATERIALS AND METHODS: During 18 months, all pregnant women attending a University Hospital underwent a 50-g, 1-h NDDG GCT for universal screening (n = 1092). The following appointment consisted of a 75-g, 2-h GTT (WHO test), independently of the prior result. Women with an abnormal 50-g and/or an abnormal 75-g, received a 100-g, 3-h GTT; subjects with only one abnormal 3-h GTT value were not included in the accuracy analysis. Women whose diagnosis followed NDDG criteria received treatment. Obstetricians were not aware of ADA/WHO results.
RESULTS: ADA sensitivity was 100% (95%CI 98.6, 100) and specificity, 98.1% (95%CI 97.6, 98.6), whereas WHO sensitivity was 57.6% (95%CI 55.9, 59.2) and specificity, 85.1% (95%CI 84.7, 85.6). ADA results remained similar independently of obesity and age, but performed better with a family history of diabetes. Accuracy of WHO improved under selective screening, still the false negative rate ranged 40-56%.
CONCLUSIONS: We recommend replicating this validation process in other health service settings. Although WHO test is easier and less expensive than NDDG or ADA, caution is needed before deciding employment of such criteria in pregnant women.
MATERIALS AND METHODS: During 18 months, all pregnant women attending a University Hospital underwent a 50-g, 1-h NDDG GCT for universal screening (n = 1092). The following appointment consisted of a 75-g, 2-h GTT (WHO test), independently of the prior result. Women with an abnormal 50-g and/or an abnormal 75-g, received a 100-g, 3-h GTT; subjects with only one abnormal 3-h GTT value were not included in the accuracy analysis. Women whose diagnosis followed NDDG criteria received treatment. Obstetricians were not aware of ADA/WHO results.
RESULTS: ADA sensitivity was 100% (95%CI 98.6, 100) and specificity, 98.1% (95%CI 97.6, 98.6), whereas WHO sensitivity was 57.6% (95%CI 55.9, 59.2) and specificity, 85.1% (95%CI 84.7, 85.6). ADA results remained similar independently of obesity and age, but performed better with a family history of diabetes. Accuracy of WHO improved under selective screening, still the false negative rate ranged 40-56%.
CONCLUSIONS: We recommend replicating this validation process in other health service settings. Although WHO test is easier and less expensive than NDDG or ADA, caution is needed before deciding employment of such criteria in pregnant women.