China CDC weekly · 2026
Emergence of Lineage E.4 and Structural Plasticity of A28L Protein in Mpox Virus: Characterization of LCR7 Length Polymorphisms Across Lineages - Shenzhen City, Guangdong Province, China, 2023-2025.
СтатьяНазвание и аннотация: Перевод в очереди
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Peng Bo, Lyu Ziquan, Gong Wenxiao, Zhang Xiaomin, Chen Shiting, Ma Wenjuan, Shi Xiaolu, Wan Jia, Qu Jing, Dong Xiaoping
Аннотация
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: The A28L protein is involved in mpox virus (MPXV) attachment and fusion, is a major target of neutralizing antibodies, and contains regions prone to genetic variation.
WHAT IS ADDED BY THIS REPORT?: Analysis of 6,834 global and 260 Shenzhen MPXV genomes identified lineage-specific length polymorphisms in the A28L low-complexity region (LCR7). Emerging E.4 viruses exhibited complex deletion patterns and a characteristic OPG153_E293Q substitution, indicating ongoing structural diversification.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Structural variation in A28L provides additional insight into MPXV evolution beyond conventional single-nucleotide analyses. Continued surveillance of these genomic features may improve monitoring of viral transmission and the emergence of new variants.
WHAT IS ADDED BY THIS REPORT?: Analysis of 6,834 global and 260 Shenzhen MPXV genomes identified lineage-specific length polymorphisms in the A28L low-complexity region (LCR7). Emerging E.4 viruses exhibited complex deletion patterns and a characteristic OPG153_E293Q substitution, indicating ongoing structural diversification.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Structural variation in A28L provides additional insight into MPXV evolution beyond conventional single-nucleotide analyses. Continued surveillance of these genomic features may improve monitoring of viral transmission and the emergence of new variants.