The pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Dorma Maria Pia Federica, Giuliani Giuseppe, Guerra Francesco, Santelli Francesco, Esposito Alessandro, De Pastena Matteo, Turri Giulia, Pedrazzani Corrado, Kauffmann Emanuele Federico, Boggi Ugo, Solaini Leonardo, Ercolani Giorgio, Mastrangelo Laura, Jovine Elio, Di Franco Gregorio, Morelli Luca, Mazzola Michele, Ferrari Giovanni, Langella Serena, Ferrero Alessandro, La Mendola Roberta, Abu Hilal Mohamnad, Depalma Norma, D'Ugo Stefano, Spampinato Marcello Giuseppe, Frisini Marco, Brolese Alberto, Palaia Raffaele, Belli Andrea, Cillara Nicola, Deserra Antonello, Cannavera Alessandro, Sagnotta Andrea, Mancini Stefano, Pinotti Enrico, Montuori Mauro, Coppola Alessandro, Di Benedetto Fabrizio, Coratti Andrea, COVID-AGICT Collaborative Group
Аннотация
METHODS: The primary endpoint of the study was to find out any difference in the tumoral stage of surgically treated PC patients between 2019 and 2020. Surgical and oncological outcomes of the entire cohort of patients were also appraised dividing the entire peri-pandemic period into six three-month timeframes to balance out the comparison between 2019 and 2020.
RESULTS: Overall, a total of 1815 patients were surgically treated during 2019 and 2020 in 14 Italian surgical Units. In 2020, the rate of patients treated with an advanced pathological stage was not different compared to 2019 (p = 0.846). During the pandemic, neoadjuvant chemotherapy (NCT) has dropped significantly (6.2% vs 21.4%, p < 0.001) and, for patients who didn't undergo NCT, the latency between diagnosis and surgery was shortened (49.58 ± 37 days vs 77.40 ± 83 days, p < 0.001). During 2020 there was a significant increase in minimally invasive procedures (p < 0.001). The rate of postoperative complication was the same in the two years but during 2020 there was an increase of the medical ones (19% vs 16.1%, p = 0.001).
CONCLUSIONS: The post-pandemic dramatic modifications in healthcare provision, in Italy, did not significantly impair the clinical history of PC patients receiving surgical resection. The present study is one of the largest reports available on the argument and may provide the basis for long-term analyses.