Gan to kagaku ryoho. Cancer & chemotherapy · 2024
[A Case of Lynch Syndrome with Muir-Torre Syndrome].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shiraishi Takehiro, Mori Yoshiko, Chika Noriyasu, Hatano Satoshi, Matsuyama Takatoshi, Sugino Aoi, Ito Tetsuya, Suzuki Okihide, Tanabe Noriko, Ishiguro Toru, Kumagai Yoichi, Ishibashi Keiichiro, Sugawara Narumi, Fukuda Tomoo, Ishida Hideyuki
Аннотация
Muir-Torre syndrome(MTS)is a disease characterized by the simultaneous occurrence of sebaceous tumors and visceral malignant tumors. This syndrome is now considered to be a phenotypic variant of Lynch syndrome(LS). Our patient was a 58-year-old woman with a history of endometrioid adenocarcinoma of the uterine isthmus at the age of 40 years and left-sided triple negative breast cancer at the age of 44 years. At the age of 52 years, a multigene panel testing revealed a pathogenic variant in MSH2, and the patient was diagnosed with LS. During surveillance for LS in our department, a 2-mm sized intradermal nodule was found on the patient's left shoulder, at the age of 58 years. Histopathological examination of the resected intradermal nodule revealed a sebaceous adenoma. LS can present as MTS, and it is, therefore, important to conduct surveillance not only for visceral malignant tumors but also for skin tumors.