Southern medical journal · 2017
Emerging Therapeutic Strategies in Breast Cancer.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Cox Kayla, Alford Brandon, Soliman Hatem
Аннотация
The field of medical oncology is experiencing a period of rapid evolution owing to advances in the fields of genomics, tumor biology, and immunology. These disciplines have provided valuable insights into the heterogeneity between breast tumors, key oncogenic drivers, and the role of the immune system in the natural history of breast cancer. This knowledge is translating into many novel therapeutic strategies using personalized medicines, targeted drug delivery systems, and immunomodulatory agents in the treatment of both the early and metastatic stages of the disease. This review article attempts to cover the major developments in experimental therapeutics and how they relate to our understanding of breast cancer and its various biologic subtypes.
Предметные рубрики MeSH
Ado-Trastuzumab EmtansineAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsAromatase InhibitorsBreast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Drug Delivery SystemsFemaleHumansImmunotherapyIpilimumabMaytansineMolecular Targeted TherapyNivolumabPoly(ADP-ribose) Polymerase InhibitorsPrecision MedicineProtein Kinase InhibitorsErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenSelective Estrogen Receptor ModulatorsTOR Serine-Threonine KinasesTrastuzumabTriple Negative Breast Neoplasms