Cancer · 2015
Teenage acne and cancer risk in US women: A prospective cohort study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Zhang Mingfeng, Qureshi Abrar A, Fortner Renée T, Hankinson Susan E, Wei Qingyi, Wang Li-E, Eliassen A Heather, Willett Walter C, Hunter David J, Han Jiali
Аннотация
BACKGROUND: Acne reflects hormone imbalance and is a key component of several systemic diseases. We hypothesized that diagnosis of acne as a teenager might predict subsequent risk of hormone-related cancers.
METHODS: We followed 99,128 female nurses in the Nurses' Health Study II cohort for 20 years (1989-2009) and used Cox proportional hazards models to estimate the hazard ratios (HRs) of 8 specific cancers (breast, thyroid, colorectal, ovarian, cervical, and endometrial cancers, melanoma, and non-Hodgkin lymphoma) for women with a history of severe teenage acne.
RESULTS: After thoroughly adjusting for the previously known risk factors for each cancer, we found that among women with a history of severe teenage acne, the relative risk increased, with a multivariable-adjusted HR of 1.44 (95% confidence interval [CI], 1.03-2.01) for melanoma. We replicated this association in an independent melanoma case-control study of 930 cases and 1026 controls (multivariable-adjusted odds ratio, 1.27; 95% CI, 1.03-1.56). We also found that in both studies the individuals with teenage acne were more likely to have moles (52.7% vs 50.1%, P < .001 in the cohort study; and 55.2% vs 45.1%, P = .004 in the case-control study).
CONCLUSIONS: Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships.
METHODS: We followed 99,128 female nurses in the Nurses' Health Study II cohort for 20 years (1989-2009) and used Cox proportional hazards models to estimate the hazard ratios (HRs) of 8 specific cancers (breast, thyroid, colorectal, ovarian, cervical, and endometrial cancers, melanoma, and non-Hodgkin lymphoma) for women with a history of severe teenage acne.
RESULTS: After thoroughly adjusting for the previously known risk factors for each cancer, we found that among women with a history of severe teenage acne, the relative risk increased, with a multivariable-adjusted HR of 1.44 (95% confidence interval [CI], 1.03-2.01) for melanoma. We replicated this association in an independent melanoma case-control study of 930 cases and 1026 controls (multivariable-adjusted odds ratio, 1.27; 95% CI, 1.03-1.56). We also found that in both studies the individuals with teenage acne were more likely to have moles (52.7% vs 50.1%, P < .001 in the cohort study; and 55.2% vs 45.1%, P = .004 in the case-control study).
CONCLUSIONS: Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships.
Предметные рубрики MeSH
Acne VulgarisAdolescentAdultAgedBiomarkersBreast NeoplasmsCase-Control StudiesFemaleGenital Neoplasms, FemaleHumansIncidenceLymphoma, Non-HodgkinMelanomaMiddle AgedNeoplasms, Hormone-DependentOdds RatioProportional Hazards ModelsProspective StudiesRisk FactorsSkin NeoplasmsSurveys and QuestionnairesTestosteroneThyroid NeoplasmsUnited StatesYoung Adult