European journal of clinical pharmacology · 2011
Comparative adherence to oxybutynin or tolterodine among older patients.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Gomes Tara, Juurlink David N, Mamdani Muhammad M
Аннотация
PURPOSE: To compare persistence of oxybutynin or tolterodine therapy among older patients newly prescribed one of these drugs.
METHODS: We conducted a retrospective cohort study of Ontarians aged 66 years and older who were newly prescribed either drug between January 1, 2000 and December 31, 2007. Persistence with treatment was defined on the basis of refills for the drug within a grace period equal to 50% of the prescription duration.
RESULTS: We identified 31,996 patients newly treated with oxybutynin and 24,855 newly treated with tolterodine. After 2 years of follow-up, persistence on oxybutynin (9.4%) was significantly lower than that on tolterodine (13.6%, p < 0.0001). The median time to discontinuation of oxybutynin and tolterodine was 68 and 128 days, respectively.
CONCLUSIONS: Our findings suggest that the tolerability of these drugs differs substantially.
METHODS: We conducted a retrospective cohort study of Ontarians aged 66 years and older who were newly prescribed either drug between January 1, 2000 and December 31, 2007. Persistence with treatment was defined on the basis of refills for the drug within a grace period equal to 50% of the prescription duration.
RESULTS: We identified 31,996 patients newly treated with oxybutynin and 24,855 newly treated with tolterodine. After 2 years of follow-up, persistence on oxybutynin (9.4%) was significantly lower than that on tolterodine (13.6%, p < 0.0001). The median time to discontinuation of oxybutynin and tolterodine was 68 and 128 days, respectively.
CONCLUSIONS: Our findings suggest that the tolerability of these drugs differs substantially.
Предметные рубрики MeSH
AgedAged, 80 and overBenzhydryl CompoundsCohort StudiesCresolsDatabases, FactualDrug PrescriptionsFemaleFollow-Up StudiesHumansMaleMandelic AcidsMedication AdherenceMuscarinic AntagonistsNational Health ProgramsOntarioPhenylpropanolamineProportional Hazards ModelsRetrospective StudiesTolterodine TartrateUrinary Incontinence, Urge